I use this twice a day, when I get up and when I go to bed. I have been using this for a couple months. Used about 1 1/2 bottles so far. I had pain in my toes when I wore shoes, that is now gone. None of my toe nails are back to normal yet. The smaller nails seem to be getting better, but none are clear yet. gonna Keep on using this twice daily. Still have 5 bottles yet, so I am hoping by the time I get to end of them, I will have pretty feet again. I do love the toenail clippers!!!!! they get a 11 out of 10. They are super sharp and even cut thru my thick ugly nails.